Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye
نویسندگان
چکیده
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201; Institute of Ophthalmology, University College London, London EC1Y 8TB, United Kingdom; Departments of Surgery and Cancer and Materials, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom; Centre for Ophthalmology, University of Tübingen, D-72076 Tubingen, Germany; Department of Psychology, George Mason University, Fairfax, VA 22030; and Center for Advanced Radiation Sources, The University of Chicago, Chicago, IL 60439
منابع مشابه
Correction for Thompson et al., Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye.
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD). The cause for the accumulation and retention of molecules in the sub-RPE space, however, remains an enigma. Here, we present fluorescence microscopy and X-ray diffraction evidence f...
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PURPOSE A cardinal pathological feature of age-related macular degeneration (AMD) is the deposition of extracellular material between the retinal pigment epithelium (RPE) and Bruch's membrane, pathologically described as sub-RPE deposits. Both the presence and local organization of these deposits contribute to the clinical manifestations of AMD, including localized deposits clinically recognize...
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OBJECTIVES To develop a 3-dimensional carrier system for subretinal transplantation of human fetal retinal pigment epithelial (HFRPE) cells and to assess their growth pattern in the rabbit subretinal space. METHODS After a standard 3-port vitrectomy, HFRPE cells grown as microspheres on cross-linked fibrinogen were introduced into the subretinal space of rabbits. The eyes were studied at 7, 1...
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